An MIT study published today in Nature provides new evidence for how specific cells and circuits become vulnerable in Alzheimer’s disease, and hones in on other factors that may help some people show resilience to cognitive decline, even amid clear signs of disease pathology. To highlight potential targets for interventions to sustain cognition and memory, the authors engaged in a novel comparison of gene expression across multiple brain regions in people with or without Alzheimer’s disease, and conducted lab experiments to test and validate their major findings.

As artificial intelligence models become increasingly prevalent and are integrated into diverse sectors like health care, finance, education, transportation, and entertainment, understanding how they work under the hood is critical. Interpreting the mechanisms underlying AI models enables us to audit them for safety and biases, with the potential to deepen our understanding of the science behind intelligence itself.

Neural networks have made a seismic impact on how engineers design controllers for robots, catalyzing more adaptive and efficient machines. Still, these brain-like machine-learning systems are a double-edged sword: Their complexity makes them powerful, but it also makes it difficult to guarantee that a robot powered by a neural network will safely accomplish its task.

It is estimated that about 70 percent of the energy generated worldwide ends up as waste heat.

Because machine-learning models can give false predictions, researchers often equip them with the ability to tell a user how confident they are about a certain decision. This is especially important in high-stake settings, such as when models are used to help identify disease in medical images or filter job applications.

When it comes to artificial intelligence, appearances can be deceiving. The mystery surrounding the inner workings of large language models (LLMs) stems from their vast size, complex training methods, hard-to-predict behaviors, and elusive interpretability.

As a child, I often accompanied my mother to the grocery store. As she pulled out her card to pay, I heard the same phrase like clockwork: "Go bag the groceries." It was not my favorite task.

A new tool makes it easier for database users to perform complicated statistical analyses of tabular data without the need to know what is going on behind the scenes.

Artificial intelligence models often play a role in medical diagnoses, especially when it comes to analyzing images such as X-rays. However, studies have found that these models don’t always perform well across all demographic groups, usually faring worse on women and people of color.

The impact of artificial intelligence will never be equitable if there’s only one company that builds and controls the models (not to mention the data that go into them). Unfortunately, today’s AI models are made up of billions of parameters that must be trained and tuned to maximize performance for each use case, putting the most powerful AI models out of reach for most people and companies.