The Networks and Mobile Systems research group has conducted research in many areas of networking since 1998, including wireless networks, internet architecture, and network security.

The MIT Data-Driven Inference Group (also known as the MIT Clinical and Applied Machine Learning Group) works toward developing machine learning and computer vision techniques to improve outcomes in medicine, finance, and sports.

The Programming Systems Group investigates the semantics, design, and implementation of programming systems (programming languages, compilers, and runtime systems).

The MIT-Harvard Center for Brains, Minds and Machines aims to create a new field — the Science and Engineering of Intelligence — that is dedicated to developing a computationally based understanding of human intelligence and establishing an engineering practice based on that understanding. The multi-institutional collaboration is a National Science Foundation funded Science and Technology Center focused on the interdisciplinary study of intelligence.

The Clinical Decision-Making Group's mission is to explore and further the application of  technology and artificial intelligence to clinical situations. They also focus on the gathering, availability, security, and  use of medical information throughout the human “life  cycle” and beyond, in order to help support the vital nature  of medical practice.